Pathology of Flu/ Influenza virus

When flu virus is driven into the respiratory tract, by aerosol or by contact with saliva or other respiratory secretions from an affected individual, it attaches and replicates in epithelial cells. The virus replicates in cells of both the lower and upper respiratory tract. Viral replication combined with the immune response to infection lead to destruction and loss of cells lining the respiratory tract. 

  • Tracheobronchial Changes in Influenza
  • Ciliated pseudostratified epitheepithelium of trachea and bronchi
  • Ducts of the mucus glands
  • Epithelium of the bronchioli
  • Other histologic changes
  • In situ hybridization or immunohisto-chemical analysis for influenza virus in sections of the upper airway
  • Evidence of epithelial repair and regeneration
  • Influenza Virus Pneumonia
  • Alveolitis

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